منابع مشابه
New developments in genetics of myositis.
PURPOSE OF REVIEW This article reviews the advances that have been made in our understanding of the genetics of the idiopathic inflammatory myopathies (IIM) in the past 2 years, with a particular focus on polymyositis, dermatomyositis and inclusion body myositis. RECENT FINDINGS Two large human leukocyte antigen (HLA) imputation studies have confirmed a strong association with the 8.1 ancestr...
متن کاملGenetics in inclusion body myositis
PURPOSE OF REVIEW To review the advances in our understanding of the genetics of inclusion body myositis (IBM) in the past year. RECENT FINDINGS One large genetic association study focusing on immune-related genes in IBM has refined the association within the human leukocyte antigen (HLA) region to HLA-DRB1 alleles, and identified certain amino acid positions in HLA-DRB1 that may explain this...
متن کاملOngoing Developments in Sporadic Inclusion Body Myositis
Sporadic inclusion body myositis (IBM) is an acquired muscle disorder associated with ageing, for which there is no effective treatment. Ongoing developments include: genetic studies that may provide insights regarding the pathogenesis of IBM, improved histopathological markers, the description of a new IBM autoantibody, scrutiny of the diagnostic utility of clinical features and biomarkers, th...
متن کاملGenetics of primary ovarian insufficiency: new developments and opportunities
BACKGROUND Primary ovarian insufficiency (POI) is characterized by marked heterogeneity, but with a significant genetic contribution. Identifying exact causative genes has been challenging, with many discoveries not replicated. It is timely to take stock of the field, outlining the progress made, framing the controversies and anticipating future directions in elucidating the genetics of POI. ...
متن کاملSome New Developments in Small Area Estimation
Small area estimation has received a lot of attention in recent years due to growing demand for reliable small area statistics. Traditional area-specific estimators may not provide adequate precision because sample sizes in small areas are seldom large enough. This makes it necessary to employ indirect estimators based on linking models. Basic area level and unit level models have been extensiv...
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ژورنال
عنوان ژورنال: Current Opinion in Rheumatology
سال: 2016
ISSN: 1040-8711,1531-6963
DOI: 10.1097/bor.0000000000000328